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Article

Postnatal development and progression of renal dysplasia in cyclooxygenase-2 null mice.

Kidney international - 1 Dec 2000

Norwood V F, Morham S G, Smithies O

Abstract excerpt

BACKGROUND: Genetic ablation of cyclooxygenase-2 (COX-2) resulted in cystic renal dysplasia and early death in adult mice. The ontologic development of the renal pathology and the biochemical and physiological abnormalities associated with the dysplasia are unknown. METHODS: Mice homozygous for a targeted deletion of COX-2 (-/-) were compared with wild-type littermates (+/+). Somatic and kidney growth and renal...

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Identifiers

PMID: 11115063
DOI: 10.1046/j.1523-1755.2000.00413.x

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