Article
A di-leucine sequence and a cluster of acidic amino acids are required for dynamic retention in the endosomal recycling compartment of fibroblasts.
Molecular biology of the cell - 1 Feb 2001
Johnson A O, Lampson M A, McGraw T E
Abstract excerpt
Insulin-regulated aminopeptidase (IRAP), a transmembrane aminopeptidase, is dynamically retained within the endosomal compartment of fibroblasts. The characteristics of this dynamic retention are rapid internalization from the plasma membrane and slow recycling back to the cell surface. These specialized trafficking kinetics result in <15% of IRAP on the cell surface at steady state, compared with 35% of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.