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Article

Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin.

The Journal of biological chemistry - 11 Aug 2017

Schmidt Esben G W, Hvam Michael L, Antunes Filipa, Cameron Jason, Viuff Dorthe, Andersen Birgitte, Kristensen Nanna N, Howard Kenneth A

Abstract excerpt

Albumin is the most abundant plasma protein involved in the transport of many compounds, such as fatty acids, bilirubin, and heme. The endothelial cellular neonatal Fc receptor (FcRn) has been suggested to play a central role in maintaining high albumin plasma levels through a cellular recycling pathway. However, direct mapping of this process is still lacking. This work presents the use of wild-type and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28637874
DOI: 10.1074/jbc.M117.794248
PMCID: PMC5555191

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