Article
Intracellular degradation of the transport-impaired human PiZ alpha 1-antitrypsin variant. Biochemical mapping of the degradative event among compartments of the secretory pathway.
The Journal of biological chemistry - 15 Aug 1990
Le A, Graham K S, Sifers R N
Abstract excerpt
The naturally occurring PiZ and Pi NullHong Kong variants of the human secretory protein alpha 1-antitrypsin (AAT) are retained within an early compartment of the secretory pathway. Intracellular degradation of these transport-impaired secretory proteins is initiated 30-45 min following their syn...
Topics
- Animals
- Cell Line
- DNA, Recombinant
- Endoplasmic Reticulum
- Genetic Variation
- Genetic Vectors
- Humans
- Hydrogen-Ion Concentration
- Kinetics
- Liver Neoplasms, Experimental
- Mice
- Restriction Mapping