Article
Endoplasmic reticulum protein targeting of phospholamban: a common role for an N-terminal di-arginine motif in ER retention?
PloS one - 9 Jul 2010
Sharma Parveen, Ignatchenko Vladimir, Grace Kevin, Ursprung Claudia, Kislinger Thomas, Gramolini Anthony O
Abstract excerpt
BACKGROUND: Phospholamban (PLN) is an effective inhibitor of the sarco(endo)plasmic reticulum Ca(2+)-ATPase, which transports Ca(2+) into the SR lumen, leading to muscle relaxation. A mutation of PLN in which one of the di-arginine residues at positions 13 and 14 was deleted led to a severe, early onset dilated cardiomyopathy. Here we were interested in determining the cellular mechanisms involved in this...
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