Article
Common hepatic lipase gene promoter variant determines clinical response to intensive lipid-lowering treatment.
Circulation - 13 Feb 2001
Zambon A, Deeb S S, Brown B G, Hokanson J E, Brunzell J D
Abstract excerpt
BACKGROUND: The common -514 C-->T polymorphism in the promoter region of the hepatic lipase (HL) gene affects HL activity. The C allele is associated with higher HL activity, more dense and atherogenic LDL, and lower HDL(2) cholesterol. Intensive lipid-lowering therapy lowers HL activity, increases LDL and HDL buoyancy, and promotes coronary artery disease (CAD) regression. We tested the hypothesis that subjects...
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