Article
Common C-to-T substitution at position -480 of the hepatic lipase promoter associated with a lowered lipase activity in coronary artery disease patients.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 1997
Jansen H, Verhoeven A J, Weeks L, Kastelein J J, Halley D J, van den Ouweland A, Jukema J W, Seidell J C, Birkenhäger J C
Abstract excerpt
We studied the molecular basis of low hepatic lipase (HL) activity in normolipidemic male patients with angiographically documented coronary artery disease (CAD). In 18 subjects with a lowered HL activity (< 225 mU/mL), all nine exons of the HL gene and part of the promoter region (nucleotides -5...
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