Article
Genetic variation in the hepatic lipase gene is associated with combined hyperlipidemia, plasma lipid concentrations, and lipid-lowering drug response.
American heart journal - 1 Dec 2005
Cenarro Ana, Artieda Marta, Gonzalvo Carmen, Meriño-Ibarra Erardo, Arístegui Rosa, Gañán Alberto, Díaz Cristina, Sol Josep María, Pocoví Miguel, Civeira Fernando
Abstract excerpt
BACKGROUND: Combined hyperlipidemia (CHL) is a very frequent dyslipidemia, being lipid-lowering drugs often necessary in its management. Some genetic loci have been associated with CHL, and modulation of lipid-lowering treatment by genetic polymorphisms has been reported. We have investigated whether common polymorphisms in the hepatic lipase gene (LIPC) influence the baseline lipid concentration and the response...
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