Article
Functional characterization of 4 polymorphisms in promoter region of hepatic lipase gene.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2000
van't Hooft F M, Lundahl B, Ragogna F, Karpe F, Olivecrona G, Hamsten A
Abstract excerpt
Hepatic lipase (HL) is a lipolytic enzyme involved in the metabolism of plasma lipoproteins, especially high density lipoproteins. Association studies have provided strong evidence for relations of common mutations in the promoter region of the HL gene to postheparin plasma HL activity and the plasma high density lipoprotein cholesterol concentration, but the functional relevance of these polymorphisms has not...
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