Common variants in the promoter of the hepatic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 cholesterol.

doi:10.1161/01.atv.18.11.1723

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Article

Common variants in the promoter of the hepatic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 cholesterol.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 1998

Zambon A, Deeb S S, Hokanson J E, Brown B G, Brunzell J D

Abstract excerpt

Increased hepatic lipase (HL) activity is associated with small, dense, low density lipoprotein (LDL) and low high density lipoprotein2 (HDL2) cholesterol (-C) levels. A polymorphism in the promoter region of the HL gene (LIPC) is associated with HDL-C levels. To test whether this association is...

Topics

Adult
Alleles
Cholesterol, HDL
Female
Genetic Variation
Humans
Lipase
Lipoproteins, LDL
Liver
Male
Promoter Regions, Genetic

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