Article
The winged helix gene, Foxb1, controls development of mammary glands and regions of the CNS that regulate the milk-ejection reflex.
Genesis (New York, N.Y. : 2000) - 1 Feb 2001
Kloetzli J M, Fontaine-Glover I A, Brown E R, Kuo M, Labosky P A
Abstract excerpt
The ability to lactate is a process restricted to mammals and is necessary for the survival of nonhuman mammals. Female mice carrying a null mutation in the winged helix transcription factor Foxb1 (previously Mf3/Fkh5/TWH) have lactation defects on inbred genetic backgrounds. To determine the cellular basis of the Foxb1 lactation defect we have inserted a tau-lacZ lineage marker into the locus to follow the fate...
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