Mice without a functional relaxin gene are unable to deliver milk to their pups.

doi:10.1210/endo.140.1.6404

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Article

Mice without a functional relaxin gene are unable to deliver milk to their pups.

Endocrinology - 1 Jan 1999

Zhao L, Roche P J, Gunnersen J M, Hammond V E, Tregear G W, Wintour E M, Beck F

Abstract excerpt

We have used gene targeting to generate relaxin (rlx)-deficient mice. The majority (15 of 17) of homozygous (rlx-/-) mice are fertile and produce normal litters. However their mammary development is deficient; pups are unable to suckle and die within 24 h of birth unless cross-fostered to a wild-...

Topics

Alleles
Animals
Blotting, Northern
Chromosome Mapping
Female
Gene Targeting
Lactation
Mammary Glands, Animal
Mice
Mice, Inbred C57BL
Mice, Knockout
Mutation
Osmolar Concentration
Phenotype
Polymerase Chain Reaction
Pregnancy
Pubic Symphysis
Relaxin

Source

Open in PubMed

Identifiers

PMID: 9886856
DOI: 10.1210/endo.140.1.6404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9886856-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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