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Article

Mice without a functional relaxin gene are unable to deliver milk to their pups.

Endocrinology - 1 Jan 1999

Zhao L, Roche P J, Gunnersen J M, Hammond V E, Tregear G W, Wintour E M, Beck F

Abstract excerpt

We have used gene targeting to generate relaxin (rlx)-deficient mice. The majority (15 of 17) of homozygous (rlx-/-) mice are fertile and produce normal litters. However their mammary development is deficient; pups are unable to suckle and die within 24 h of birth unless cross-fostered to a wild-type (rlx+/+) foster mother. The nipples of rlx-/- animals do not enlarge significantly during pregnancy, and their...

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Identifiers

PMID: 9886856
DOI: 10.1210/endo.140.1.6404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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