Article
Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve.
Development (Cambridge, England) - 1 Oct 1996
Goddard J M, Rossel M, Manley N R, Capecchi M R
Abstract excerpt
Mice were generated with targeted disruptions in the hoxb-1 gene. Two separate mutations were created: the first disrupts only the homeodomain and the second inactivates the first exon as well as the homeodomain. The phenotypes associated with these two mutant alleles are indistinguishable in sur...
Topics
- Animals
- Cell Movement
- Cell Nucleus
- Facial Nerve
- Female
- Fertility
- Gene Expression
- Homeodomain Proteins
- Male
- Mice
- Mice, Inbred C57BL
- Motor Neurons
- Muscles
- Mutation
- Neural Crest
- Paralysis