Article
Lactation is disrupted by alpha-lactalbumin deficiency and can be restored by human alpha-lactalbumin gene replacement in mice.
Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 1995
Stacey A, Schnieke A, Kerr M, Scott A, McKee C, Cottingham I, Binas B, Wilde C, Colman A
Abstract excerpt
Mice carrying either a deletion of the murine alpha-lactalbumin (alpha-lac) gene (null allele) or its replacement by the human alpha-lac gene (humanized allele) have been generated by gene targeting. Homozygous null females are alpha-lac-deficient, produce reduced amounts of thickened milk contai...
Topics
- Alleles
- Animals
- Blotting, Western
- Female
- Gene Deletion
- Gene Expression
- Genotype
- Heterozygote
- Humans
- Lactalbumin
- Lactation
- Mammary Glands, Animal
- Mice
- Mice, Mutant Strains
- Mice, Transgenic