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Article

Lef1-dependent hypothalamic neurogenesis inhibits anxiety.

PLoS biology - 1 Aug 2017

Xie Yuanyuan, Kaufmann Dan, Moulton Matthew J, Panahi Samin, Gaynes John A, Watters Harrison N, Zhou Dingxi, Xue Hai-Hui, Fung Camille M, Levine Edward M, Letsou Anthea, Brennan K C, Dorsky Richard I

Abstract excerpt

While innate behaviors are conserved throughout the animal kingdom, it is unknown whether common signaling pathways regulate the development of neuronal populations mediating these behaviors in diverse organisms. Here, we demonstrate that the Wnt/ß-catenin effector Lef1 is required for the differentiation of anxiolytic hypothalamic neurons in zebrafish and mice, although the identity of Lef1-dependent genes and...

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Source

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Identifiers

PMID: 28837622
DOI: 10.1371/journal.pbio.2002257
PMCID: PMC5570277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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