Article
Genomic structure and loss of heterozygosity of EPHB2 in colorectal cancer.
Cancer letters - 10 Mar 2001
Oba S M, Wang Y J, Song J P, Li Z Y, Kobayashi K, Tsugane S, Hamada G S, Tanaka M, Sugimura H
Abstract excerpt
EphB2, a member of the Eph receptor protein-tyrosine kinase family, is overexpressed in several human gastrointestinal tumors. Furthermore, the EphB2 gene is localized at 1p35-p36.1, a frequently deleted region in colon and other cancers. So, despite its overexpression in some kind of tumors, we decided to study the possibility of involvement in the EphB2 gene (EPHB2) mutation in colon cancers, because some of...
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