Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The homeobox gene CDX2 in colorectal carcinoma: a genetic analysis.

British journal of cancer - 1 Jan 2001

Sivagnanasundaram S, Islam I, Talbot I, Drummond F, Walters J R, Edwards Y H

Abstract excerpt

Accumulation of mutations in tumour suppressor genes and oncogenes has been proposed to underlie the initiation and progression of sporadic colorectal cancer (CRC). Evidence is accumulating to suggest that the caudal homeobox gene CDX2 is implicated in the pathogenesis of CRC. The CDX2 transcription factor is expressed in intestinal epithelium and is markedly down-regulated in colon tumours. Furthermore, Cdx2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CDX2 Transcription Factor
Share to DNA, Neoplasm
Share to Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

Share to Polymorphism, Single-Stranded Conformational

Share to RNA, Neoplasm

Share to RNA Splicing

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 11161380
DOI: 10.1054/bjoc.2000.1544
PMCID: PMC2363702

Genes

CDX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The homeobox gene CDX2 in colorectal carcinoma: a genetic analysis.PMID 11161380Read ↗

Altered expression of CDX2 in colorectal cancersSemantic proximity Read ↗

CDX2 polymorphisms, RNA expression, and risk of colorectal cancer.Semantic proximity Read ↗

The prognostic potential of CDX2 in colorectal cancer: Harmonizing biology and clinical practiceSemantic proximity Read ↗

CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer.Semantic proximity Read ↗

The clinical perspectives of CDX2 expression in colorectal cancer: a qualitative systematic review.Semantic proximity Read ↗

Genetic alterations of the Cdx2 gene in gastric cancer.Semantic proximity Read ↗

Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instabilitySemantic proximity Read ↗

Relationship of CDX2 Loss with Molecular Features and Prognosis in Colorectal CancerSemantic proximity Read ↗

The <i>Cdx2</i> homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut developmentSemantic proximity Read ↗

Silencing of CDX2 expression in colon cancer via a dominant repression pathway.Semantic proximity Read ↗

Homeosis and intestinal tumours in Cdx2 mutant mice.Semantic proximity Read ↗

The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non–cell-autonomous mechanismsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.