Article
Expression of EphA2 and E-cadherin in colorectal cancer: correlation with cancer metastasis.
Oncology reports - 1 Mar 2004
Saito Tetsuya, Masuda Norihiro, Miyazaki Tatsuya, Kanoh Kenichi, Suzuki Hideki, Shimura Tatsuo, Asao Takayuki, Kuwano Hiroyuki
Abstract excerpt
Recently, overexpression of EphA2, a member of the Eph family of receptor tyrosine kinases, has been reported in several cancers. Reduced expression of E-cadherin, an intercellular adhesion molecule of epithelial cells, has been reported to be associated with aggressive clinicopathological phenotypes in various cancers. In epithelial cells, EphA2 and E-cadherin co-localize to sites of cell-cell contact, and it...
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