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Article

EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis.

BMC cancer - 1 Jun 2006

Kokko Antti, Laiho Päivi, Lehtonen Rainer, Korja Sanna, Carvajal-Carmona Luis G, Järvinen Heikki, Mecklin Jukka-Pekka, Eng Charis, Schleutker Johanna, Tomlinson Ian P M, Vahteristo Pia, Aaltonen Lauri A

Abstract excerpt

BACKGROUND: Ephrin receptor B2 (EPHB2) has recently been proposed as a novel tumor suppressor gene in colorectal cancer (CRC). Inactivation of the gene has been shown to correlate with progression of colorectal tumorigenesis, and somatic mutations have been reported in both colorectal and prostate tumors. METHODS: Here we have analyzed the EPHB2 gene for germline alterations in 101 individuals either with 1) CRC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16740153
DOI: 10.1186/1471-2407-6-145
PMCID: PMC1513590

Genes

EPHB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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