Article
Analysis of EphA2 expression and mutant p53 in ovarian carcinoma.
Cancer biology & therapy - 1 Oct 2006
Merritt William M, Thaker Premal H, Landen Charles N, Deavers Michael T, Fletcher Mavis S, Lin Yvonne G, Han Liz Y, Kamat Aparna A, Schmandt Rosemarie, Gershenson David M, Kinch Michael S, Sood Anil K
Abstract excerpt
The EphA2 tyrosine kinase receptor is frequently overexpressed in ovarian cancer and this feature is predictive of poor clinical outcome. Preclinical investigation has also linked EphA2 with p53. In our present study, we examined EphA2 and p53 status (both expression and full-length mutation status) in 6 ovarian cell lines and 79 human ovarian cancers to determine potential associations. EphA2 was overexpressed...
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