Article
Regulation of IL-4 expression by activation of individual alleles.
Immunity - 1 Aug 1998
Rivière I, Sunshine M J, Littman D R
Abstract excerpt
To study the in vivo role of IL-4-expressing cells, we developed a strategy to tag these cells, by generating mice in which one IL-4 allele was replaced with a cDNA encoding the human CD2 (huCD2) cell-surface molecule. Expression of the huCD2 reporter was, like IL-4, restricted to the appropriate...
Topics
- Alleles
- Animals
- CD2 Antigens
- DNA, Complementary
- Gene Expression Regulation
- Genes, Reporter
- Genetic Vectors
- Interleukin-4
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Transgenic
- Receptors, Antigen, T-Cell
- Recombination, Genetic
- Signal Transduction
- Stochastic Processes
- Th2 Cells