Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells.

doi:10.1126/science.281.5381.1352

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Article

Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells.

Science (New York, N.Y.) - 28 Aug 1998

Bix M, Locksley R M

Abstract excerpt

How an individual effector T cell acquires a particular cytokine expression pattern from many possible patterns remains unclear. CD4+ T cells from F1 mice, which allowed assignment of the parental origin of interleukin-4 (IL-4) transcripts, were divided into clones that expressed IL-4 biallelical...

Topics

Alleles
Animals
CD4-Positive T-Lymphocytes
Crosses, Genetic
Cytokines
DNA, Complementary
Female
Gene Expression Regulation
Interleukin-4
Male
Mice
Mice, Inbred BALB C
Mice, Inbred Strains
Polymerase Chain Reaction

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