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Article

Biallelic expression of the IL-2 locus under optimal stimulation conditions.

European journal of immunology - 1 Aug 2000

Chiodetti L, Barber D L, Schwartz R H

Abstract excerpt

Recent experiments have suggested that the IL-2 locus is monoallelically expressed. We tested this hypothesis using TCR-transgenic mice carrying one inactivated IL-2 allele. The frequency in single-cell assays of IL-2-producing cells following optimal stimulation by antigen and antigen-presenting cells was equivalent to that from wild-type mice, but the amount of IL-2 produced per cell was twofold less. Similar...

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Identifiers

PMID: 10940906
DOI: 10.1002/1521-4141(2000)30:8<2157::AID-IMMU2157>3.0.CO;2-#

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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