Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.

Abstract excerpt

Signal-induced alternative splicing of the CD45 gene in human T cells is essential for proper immune function. Skipping of the CD45 variable exons is controlled, in large part, by the recruitment of PSF to the pre-mRNA substrate upon T cell activation; however, the signaling cascade leading to exon exclusion has remained elusive. Here we demonstrate that in resting T cells PSF is directly phosphorylated by GSK3,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Glycogen Synthase Kinase 3
• Share to Indoles
• Share to Leukocyte Common Antigens