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Article

Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge.

Science (New York, N.Y.) - 2 Jan 1998

Majeti R, Bilwes A M, Noel J P, Hunter T, Weiss A

Abstract excerpt

The function and regulation of the receptorlike transmembrane protein tyrosine phosphatases (RPTPs) are not well understood. Ligand-induced dimerization inhibited the function of the epidermal growth factor receptor (EGFR)-RPTP CD45 chimera (EGFR-CD45) in T cell signal transduction. Properties of mutated EGFR-CD45 chimeras supported a general model for the regulation of RPTPs, derived from the crystal structure...

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Source

Identifiers

PMID: 9417031
DOI: 10.1126/science.279.5347.88

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CD45. A prototype for transmembrane protein tyrosine phosphatases.Semantic proximity Read ↗

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