Article
Detection of embB codon 306 mutations in ethambutol resistant Mycobacterium tuberculosis directly from sputum samples: a low-cost, rapid approach.
Molecular and cellular probes - 1 Feb 2001
Rinder H, Mieskes K T, Tortoli E, Richter E, Casal M, Vaquero M, Cambau E, Feldmann K, Löscher T
Abstract excerpt
Substitutions of codon 306 in the gene embB are the most common mutations found in ethambutol resistant Mycobacterium tuberculosis. The characterization of these mutations has been hampered by the need for prior cultivation of the mycobacteria, or the need for DNA sequencing, or both. Here, we describe a simple and culture-independent technique to detect embB codon 306 mutations directly from sputum samples,...
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