Role of embB codon 306 mutations in Mycobacterium tuberculosis revisited: a novel association with broad drug resistance and IS6110 clustering rather than ethambutol resistance.

doi:10.1128/AAC.49.9.3794-3802.2005

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Role of embB codon 306 mutations in Mycobacterium tuberculosis revisited: a novel association with broad drug resistance and IS6110 clustering rather than ethambutol resistance.

Antimicrobial agents and chemotherapy - 1 Sept 2005

Hazbón Manzour Hernando, Bobadilla del Valle Miriam, Guerrero Marta Inírida, Varma-Basil Mandira, Filliol Ingrid, Cavatore Magali, Colangeli Roberto, Safi Hassan, Billman-Jacobe Helen, Lavender Caroline, Fyfe Janet, García-García Lourdes, Davidow Amy, Brimacombe Michael, León Clara Inés, Porras Tania, Bose Mridula, Chaves Fernando, Eisenach Kathleen D, Sifuentes-Osornio José, Ponce de León Alfredo, Cave M Donald, Alland David

Abstract excerpt

Mutations at position 306 of embB (embB306) have been proposed as a marker for ethambutol resistance in Mycobacterium tuberculosis; however, recent reports of embB306 mutations in ethambutol-susceptible isolates caused us to question the biological role of this mutation. We tested 1,020 clinical M. tuberculosis isolates with different drug susceptibility patterns and of different geographical origins for...

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Identifiers

PMID: 16127055
DOI: 10.1128/AAC.49.9.3794-3802.2005
PMCID: PMC1195424

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