Article
Mycobacterium tuberculosis embB codon 306 mutations confer moderately increased resistance to ethambutol in vitro and in vivo.
Antimicrobial agents and chemotherapy - 1 Jun 2011
Plinke Claudia, Walter Kerstin, Aly Sahar, Ehlers Stefan, Niemann Stefan
Abstract excerpt
Ethambutol (EMB) is a major component of the first-line therapy of tuberculosis. Mutations in codon 306 of embB (embB306) were suggested as a major resistance mechanism in clinical isolates. To directly analyze the impact of individual embB306 mutations on EMB resistance, we used allelic exchange experiments to generate embB306 mutants of M. tuberculosis H37Rv. The level of EMB resistance conferred by particular...
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