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Article

Detection of ethambutol-resistant Mycobacterium tuberculosis strains by multiplex allele-specific PCR assay targeting embB306 mutations.

Journal of clinical microbiology - 1 May 2002

Mokrousov Igor, Narvskaya Olga, Limeschenko Elena, Otten Tatiana, Vyshnevskiy Boris

Abstract excerpt

We describe a multiplex allele-specific (MAS)-PCR assay to detect simultaneously mutations in the first and third bases of the embB gene codon 306ATG. These mutations are known to confer ethambutol (EMB) resistance in the majority of clinical Mycobacterium tuberculosis isolates worldwide. The mutated bases are revealed depending on the presence or absence of the respective indicative fragments amplified from the...

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Identifiers

PMID: 11980930
DOI: 10.1128/JCM.40.5.1617-1620.2002
PMCID: PMC130919

Genes

EMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Detection of ethambutol-resistant Mycobacterium tuberculosis strains by multiplex allele-specific PCR assay targeting embB306 mutations.PMID 11980930Read ↗

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