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Article

Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations.

Antimicrobial agents and chemotherapy - 1 Aug 1997

Sreevatsan S, Stockbauer K E, Pan X, Kreiswirth B N, Moghazeh S L, Jacobs W R, Telenti A, Musser J M

Abstract excerpt

Ethambutol [(S,S')-2,2'-(ethylenediimino)di-1-butanol; EMB], is a first-line drug used to treat tuberculosis. To gain insight into the molecular basis of EMB resistance, we characterized the 10-kb embCAB locus in 16 EMB-resistant and 3 EMB-susceptible genetically distinct Mycobacterium tuberculos...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9257740
DOI: 10.1128/AAC.41.8.1677
PMCID: PMC163984

Genes

EMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9257740-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations.PMID 9257740Read ↗

Role of embB in natural and acquired resistance to ethambutol in mycobacteria.Semantic proximity Read ↗

Mutation at embB codon 306, a potential marker for the identification of multidrug resistance associated with ethambutol in Mycobacterium tuberculosis.Semantic proximity Read ↗

Novel mutations within the embB gene in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis.Semantic proximity Read ↗

Mutations in the embB locus among Korean clinical isolates of Mycobacterium tuberculosis resistant to ethambutol.Semantic proximity Read ↗

Novel mutations in emb B gene of ethambutol resistant isolates of Mycobacterium tuberculosis: a preliminary report.Semantic proximity Read ↗

Frequency of mutational changes in the embB among the ethambutol-resistant strains of Mycobacterium tuberculosis in Iran.Semantic proximity Read ↗

embCAB sequence variation among ethambutol-resistant Mycobacterium tuberculosis isolates without embB306 mutation.Semantic proximity Read ↗

Analysis of <i>embCAB</i> Mutations Associated with Ethambutol Resistance in Multidrug-Resistant Mycobacterium tuberculosis Isolates from ChinaSemantic proximity Read ↗

Allelic exchange and mutant selection demonstrate that common clinical embCAB gene mutations only modestly increase resistance to ethambutol in Mycobacterium tuberculosis.Semantic proximity Read ↗

Characterization of the embB gene in Mycobacterium tuberculosis isolates from Barcelona and rapid detection of main mutations related to ethambutol resistance using a low-density DNA array.Semantic proximity Read ↗

Polymorphisms in Rv3806c (ubiA) and the upstream region of embA in relation to ethambutol resistance in clinical isolates of Mycobacterium tuberculosis from North India.Semantic proximity Read ↗

Molecular Analysis of the embCAB Locus and embR Gene Involved in Ethambutol Resistance in Clinical Isolates of Mycobacterium tuberculosis in France.Semantic proximity Read ↗

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