Article
Methylenetetrahydrofolate reductase genotypes and predisposition to atherothrombotic disease; evidence that all three MTHFR C677T genotypes confer different levels of risk.
European heart journal - 1 Feb 2001
Kluijtmans L A, Whitehead A S
Abstract excerpt
AIMS: Elevated plasma homocysteine is an independent risk factor for atherothrombotic disease. Individuals homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C allele exclusively accumulate 5methyltetrahydrofolate, the methyl donor for homocysteine remethylation, in their red blood cells; this contrasts with 677 TT homozygotes who also accumulate significant levels of non-methylated folate...
Topics
- Coronary Artery Disease
- Folic Acid
- Genetic Predisposition to Disease
- Genotype
- Homocysteine
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Mutation
- Oxidoreductases Acting on CH-NH Group Donors