Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis.

doi:10.1161/01.STR.0000169946.31639.af

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Article

Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis.

Stroke - 1 Jul 2005

Cronin Simon, Furie Karen L, Kelly Peter J

Abstract excerpt

BACKGROUND: Data are conflicting concerning ischemic stroke risk associated with a common polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase (MTHFR 677C-->T), which predisposes to hyperhomocystinemia in vivo. METHODS: We performed a systematic review and meta-analysis of published relevant literature. We included cohort, case-control, or cross-sectional studies reporting the frequencies of...

Topics

Adult
Aged
Alleles
Brain Ischemia
Female
Folic Acid
Genetic Predisposition to Disease
Heterozygote
Homozygote
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Mutation
Odds Ratio
Phenotype
Polymorphism, Genetic
Risk

Source

Open in PubMed

Identifiers

PMID: 15947278
DOI: 10.1161/01.STR.0000169946.31639.af

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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