Article
Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians.
Circulation - 15 Nov 1996
Ma J, Stampfer M J, Hennekens C H, Frosst P, Selhub J, Horsford J, Malinow M R, Willett W C, Rozen R
Abstract excerpt
BACKGROUND: Hyperhomocysteinemia appears to be an independent risk factor for coronary disease. Elevated levels of plasma total homocysteine (tHCY) can result from genetic or nutrient-related disturbances in the transsulfuration or remethylation pathways for homocysteine metabolism. The enzyme 5,...
Topics
- Adult
- Aged
- Aged, 80 and over
- Folic Acid
- Genotype
- Homocysteine
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Myocardial Infarction
- Oxidoreductases Acting on CH-NH Group Donors
- Physicians
- Polymorphism, Genetic
- Risk Factors
- United States