Article
The interaction between MTHFR 677 C-->T genotype and folate status is a determinant of coronary atherosclerosis risk.
The Journal of nutrition - 1 May 2003
Girelli Domenico, Martinelli Nicola, Pizzolo Francesca, Friso Simonetta, Olivieri Oliviero, Stranieri Chiara, Trabetti Elisabetta, Faccini Giovanni, Tinazzi Elisa, Pignatti Pier Franco, Corrocher Roberto
Abstract excerpt
The 677 C-->T polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene interacts with folate status in determining elevated total plasma levels of homocysteine, a risk factor for coronary atherosclerotic disease (CAD). The present study had the following goals: 1) to define the 677 C-->T genotype-specific threshold values of both plasma and RBC folate, associated with hyperhomocysteinemia (>15...
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