Article
Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci.
Genomics - 1 Jan 2001
Sugiyama F, Churchill G A, Higgins D C, Johns C, Makaritsis K P, Gavras H, Paigen B
Abstract excerpt
To investigate the genetic control of salt-induced hypertension, we performed a quantitative trait locus analysis on male mice from a reciprocal backcross between the salt-sensitive C57BL/6J and the normotensive A/J inbred mouse strains after they were provided with water containing 1% salt for 2 weeks. Genome-wide scans performed on these mice and analyzed with a combination of conventional marker-based...
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