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Article

Genome scan for blood pressure loci in mice.

Hypertension (Dallas, Tex. : 1979) - 1 Oct 1999

Wright F A, O'Connor D T, Roberts E, Kutey G, Berry C C, Yoneda L U, Timberlake D, Schlager G

Abstract excerpt

Hypertension is a complex trait of unknown cause in humans. Mice of the inbred strain BPH/2 serve as a rodent model of human hypertension and display elevated blood pressure compared with the hypotensive strain BPL/1. An F2 intercross of BPH/2 and BPL/1 and 2 backcrosses of BPL/1 with Mus spretus were used to perform interval linkage mapping for systolic blood pressure in a genome scan. Significant linkage was...

Topics

Alleles
Animals
Blood Pressure
Chromosomes, Human, Pair 10
Disease Models, Animal
Genetic Linkage
Genome
Genotype
Humans
Hypertension
Mice
Mice, Inbred Strains

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PMID: 10523337
DOI: 10.1161/01.hyp.34.4.625

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