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Article

Functional Captures of Multiple Human Quantitative Trait Loci Regulating Blood Pressure with the Use of Orthologs in Genetically Defined Rat Models.

The Canadian journal of cardiology - 1 May 2020

Deng Alan Y, Ménard Annie

Abstract excerpt

BACKGROUND: Most signals from human genome-wide association studies (GWAS) for blood pressure (BP) are single-nucleotide polymorphisms (SNPs). It was unknown if such SNPs can functionally affect BP. Because BP is similar between humans and rodents, unraveling basic mechanisms from rodents can reveal the same BP-modulating mechanisms in humans originating from their common ancestors while overcoming limitations in...

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Identifiers

PMID: 32389346
DOI: 10.1016/j.cjca.2020.03.012

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