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Article

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics.

PLoS genetics - 1 Aug 2009

Koutnikova Hana, Laakso Markku, Lu Lu, Combe Roy, Paananen Jussi, Kuulasmaa Teemu, Kuusisto Johanna, Häring Hans-Ulrich, Hansen Torben, Pedersen Oluf, Smith Ulf, Hanefeld Markolf, Williams Robert W, Auwerx Johan

Abstract excerpt

Hypertension is a major health problem of largely unknown genetic origins. To identify new genes responsible for hypertension, genetic analysis of recombinant inbred strains of mice followed by human association studies might prove powerful and was exploited in our current study. Using a set of 27 recombinant BXD strains of mice we identified a quantitative trait locus (QTL) for blood pressure (BP) on distal...

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PMID: 19662162
DOI: 10.1371/journal.pgen.1000591
PMCID: PMC2715105

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Source receipt: pubmed, retrieved 7 Sept 2026.

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