Article
Genetic analysis of blood pressure in 8 mouse intercross populations.
Hypertension (Dallas, Tex. : 1979) - 1 Oct 2009
Feng Minjie, Deerhake Marion E, Keating Ryan, Thaisz Jill, Xu Lingfei, Tsaih Shirng-Wern, Smith Randy, Ishige Taiichiro, Sugiyama Fumihiro, Churchill Gary A, DiPetrillo Keith
Abstract excerpt
The genetic basis of hypertension is well established, yet very few genes that cause common forms of hypertension are known. Quantitative trait locus (QTL) analyses in rodent models can guide the search for human hypertension genes, but the excellent genetic resources for mice have been underused in this regard. To address this issue, we surveyed blood pressure variation in mice from 37 inbred strains and...
Topics
- Animals
- Blood Pressure
- Chromosome Mapping
- Disease Models, Animal
- Female
- Genotype
- Hypertension
- Male
- Mice
- Mice, Inbred Strains
- Phenotype
- Quantitative Trait Loci