Article
Osteoblastic cells regulate the haematopoietic stem cell niche.
Nature - 23 Oct 2003
Calvi L M, Adams G B, Weibrecht K W, Weber J M, Olson D P, Knight M C, Martin R P, Schipani E, Divieti P, Bringhurst F R, Milner L A, Kronenberg H M, Scadden D T
Abstract excerpt
Stem cell fate is influenced by specialized microenvironments that remain poorly defined in mammals. To explore the possibility that haematopoietic stem cells derive regulatory information from bone, accounting for the localization of haematopoiesis in bone marrow, we assessed mice that were genetically altered to produce osteoblast-specific, activated PTH/PTHrP receptors (PPRs). Here we show that PPR-stimulated...
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