Article
Conditionally immortalized murine osteoblasts lacking the type 1 PTH/PTHrP receptor.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 1998
Divieti P, Lanske B, Kronenberg H M, Bringhurst F R
Abstract excerpt
Osteoblasts synthesize and mineralize bone matrix and are principal target cells for parathyroid hormone (PTH). The type 1 PTH/PTH-related protein (PTHrP) receptor (PTH1R), cloned from rat osteoblastic cells, activates multiple intracellular signaling mechanisms. The specific roles of these PTH1R signals, or of responses to other types of PTH receptors that may be expressed, in regulating osteoblast function are...
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