Article
Conditionally immortalized murine osteoblasts lacking the type 1 PTH/PTHrP receptor.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 1998
Divieti P, Lanske B, Kronenberg H M, Bringhurst F R
Abstract excerpt
Osteoblasts synthesize and mineralize bone matrix and are principal target cells for parathyroid hormone (PTH). The type 1 PTH/PTH-related protein (PTHrP) receptor (PTH1R), cloned from rat osteoblastic cells, activates multiple intracellular signaling mechanisms. The specific roles of these PTH1R...
Topics
- Adenylyl Cyclases
- Alkaline Phosphatase
- Alleles
- Animals
- Blotting, Western
- Calcification, Physiologic
- Cattle
- Cell Line, Transformed
- Cell Separation
- Cyclic AMP
- Humans
- Mice
