Article
The interplay of osteogenesis and hematopoiesis: expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrow.
The Journal of cell biology - 20 Dec 2004
Kuznetsov Sergei A, Riminucci Mara, Ziran Navid, Tsutsui Takeo W, Corsi Alessandro, Calvi Laura, Kronenberg Henry M, Schipani Ernestina, Robey Pamela Gehron, Bianco Paolo
Abstract excerpt
The ontogeny of bone marrow and its stromal compartment, which is generated from skeletal stem/progenitor cells, was investigated in vivo and ex vivo in mice expressing constitutively active parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP; caPPR) under the control of the 2.3-kb bone-specific mouse Col1A1 promoter/enhancer. The transgene promoted increased bone formation within...
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