Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.

Scientific reports - 7 Mar 2017

Edlund Anna, Pedersen Morten Gram, Lindqvist Andreas, Wierup Nils, Flodström-Tullberg Malin, Eliasson Lena

Abstract excerpt

Glucagon is the main counterregulatory hormone in the body. Still, the mechanism involved in the regulation of glucagon secretion from pancreatic alpha cells remains elusive. Dysregulated glucagon secretion is common in patients with Cystic Fibrosis (CF) that develop CF related diabetes (CFRD). CF is caused by a mutation in the Cl- channel Cystic fibrosis transmembrane conductance regulator (CFTR), but whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Colforsin
Share to Cystic Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Glucagon

Share to Glucose

Share to Membrane Potentials

Source

Open in PubMed Open full text

Identifiers

PMID: 28273890
DOI: 10.1038/s41598-017-00098-8
PMCID: PMC5428348

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.PMID 28273890Read ↗

Glucose-Sensitive CFTR Suppresses Glucagon Secretion by Potentiating KATP Channels in Pancreatic Islet α Cells.Semantic proximity Read ↗

Islet-intrinsic effects of CFTR mutation.Semantic proximity Read ↗

Cystic fibrosis-related diabetes is caused by islet loss and inflammation.Semantic proximity Read ↗

The Potential Causes of Cystic Fibrosis-Related Diabetes.Semantic proximity Read ↗

The human α cell in health and diseaseSemantic proximity Read ↗

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation stateSemantic proximity Read ↗

Disruption of glucagon receptor induces single α-cell hypersecretion through upregulation of VGFSemantic proximity Read ↗

CFTR Cl- channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis.Semantic proximity Read ↗

Activation of cAMP-dependent C1- currents in guinea-pig paneth cells without relevant evidence for CFTR expression.Semantic proximity Read ↗

CFTR regulation of epithelial sodium channel.Semantic proximity Read ↗

A cystic fibrosis pancreatic adenocarcinoma cell line.Semantic proximity Read ↗

The ablation of the Ca(v)2.3/E-type voltage-gated Ca2+ channel causes a mild phenotype despite an altered glucose induced glucagon response in isolated islets of Langerhans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.