Article
Phosphorylation of P-glycoprotein by PKA and PKC modulates swelling-activated Cl- currents.
The American journal of physiology - 1 Feb 1999
Vanoye C G, Castro A F, Pourcher T, Reuss L, Altenberg G A
Abstract excerpt
Several proteins belonging to the ATP-binding cassette superfamily can affect ion channel function. These include the cystic fibrosis transmembrane conductance regulator, the sulfonylurea receptor, and the multidrug resistance protein P-glycoprotein (MDR1). We measured whole cell swelling-activat...
Topics
- 3T3 Cells
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adenosine Triphosphate
- Animals
- Cell Membrane
- Chloride Channels
- Cyclic AMP-Dependent Protein Kinases
- DNA, Complementary
- Electric Conductivity
- Enzyme Activation
- Fibroblasts
- Mice
- Mice, Inbred BALB C
- Mutation
- Phosphorylation
- Protein Kinase C
- Transfection