Article
GTP-binding proteins inhibit cAMP activation of chloride channels in cystic fibrosis airway epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 1992
Schwiebert E M, Kizer N, Gruenert D C, Stanton B A
Abstract excerpt
Cystic fibrosis (CF) is a genetic disease characterized, in part, by defective regulation of Cl- secretion by airway epithelial cells. In CF, cAMP does not activate Cl- channels in the apical membrane of airway epithelial cells. We report here whole-cell patch-clamp studies demonstrating that pertussis toxin, which uncouples heterotrimeric GTP-binding proteins (G proteins) from their receptors, and guanosine...
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