Article
GTP-binding proteins inhibit cAMP activation of chloride channels in cystic fibrosis airway epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 1992
Schwiebert E M, Kizer N, Gruenert D C, Stanton B A
Abstract excerpt
Cystic fibrosis (CF) is a genetic disease characterized, in part, by defective regulation of Cl- secretion by airway epithelial cells. In CF, cAMP does not activate Cl- channels in the apical membrane of airway epithelial cells. We report here whole-cell patch-clamp studies demonstrating that per...
Topics
- Aluminum
- Aluminum Compounds
- Cell Line
- Cell Line, Transformed
- Cells, Cultured
- Chloride Channels
- Cyclic AMP
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Epithelium
- Fluorides
- Fluorine
- GTP-Binding Proteins
- Genotype
- Guanosine 5'-O-(3-Thiotriphosphate)
- Guanosine Diphosphate
- Humans
- Ion Channels