Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells.

American journal of respiratory cell and molecular biology - 1 Sept 2003

Cobb Bryan R, Fan Lijuan, Kovacs Timea E, Sorscher Eric J, Clancy John P

Abstract excerpt

We investigated cystic fibrosis transmembrane conductance regulator (CFTR) activation by clinically used phosphodiesterase inhibitors (PDEis) in Calu-3 cell monolayers alone and in combination with A2B adenosine receptor stimulation. This receptor pathway has previously been shown to activate wild-type and mutant CFTR molecules. Several PDEis, including milrinone, cilostazol (Pletal), papaverine, rolipram, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Deaminase
Share to Anions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chlorine

Share to Colforsin

Share to Glyburide

Share to Phosphodiesterase Inhibitors

Share to Sulfones

Share to Tetrazoles

Source

Identifiers

PMID: 12714375
DOI: 10.1165/rcmb.2002-0247OC

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells.PMID 12714375Read ↗

Activation of wild-type and deltaF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms.Semantic proximity Read ↗

Adenosine and its nucleotides activate wild-type and R117H CFTR through an A2B receptor-coupled pathway.Semantic proximity Read ↗

Receptor-mediated activation of CFTR via prostaglandin signaling pathways in the airway.Semantic proximity Read ↗

In vivo activation of the cystic fibrosis transmembrane conductance regulator mutant deltaF508 in murine nasal epithelium.Semantic proximity Read ↗

CFTR regulation of intracellular calcium in normal and cystic fibrosis human airway epithelia.Semantic proximity Read ↗

Cystic Fibrosis Transmembrane Conductance Regulator Activation by Roflumilast Contributes to Therapeutic Benefit in Chronic BronchitisSemantic proximity Read ↗

CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype.Semantic proximity Read ↗

Genetic disorders of membrane transport. II. Regulation of CFTR by small molecules including HCO3-.Semantic proximity Read ↗

Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents.Semantic proximity Read ↗

Stimulation of chloride secretion by P1 purinoceptor agonists in cystic fibrosis phenotype airway epithelial cell line CFPEo-.Semantic proximity Read ↗

A1 adenosine-receptor antagonists activate chloride efflux from cystic fibrosis cells.Semantic proximity Read ↗

Stimulation of cystic fibrosis transmembrane conductance regulator-dependent short-circuit currents across DeltaF508 murine intestines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.