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Article

Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.

Molecular and cellular biology - 1 Apr 1999

Shcherbakova P V, Kunkel T A

Abstract excerpt

Loss of DNA mismatch repair due to mutation or diminished expression of the MLH1 gene is associated with genome instability and cancer. In this study, we used a yeast model system to examine three circumstances relevant to modulation of MLH1 function. First, overexpression of wild-type MLH1 was found to cause a strong elevation of mutation rates at three different loci, similar to the mutator effect of MLH1 gene...

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Source

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Identifiers

PMID: 10082584
DOI: 10.1128/MCB.19.4.3177
PMCID: PMC84111

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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