The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts.

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Article

The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts.

Cancer research - 1 Feb 1999

Buermeyer A B, Wilson-Van Patten C, Baker S M, Liskay R M

Abstract excerpt

The DNA mismatch repair gene hMLH1 is reported to function in mutation avoidance, cell cycle checkpoint control, the cytotoxicity of various DNA-damaging agents, and transcription-coupled nucleotide excision repair. Formal proof of the involvement of hMLH1 in these processes requires single gene...

Topics

Adaptor Proteins, Signal Transducing
Animals
Antimetabolites, Antineoplastic
Base Pair Mismatch
Carrier Proteins
Cells, Cultured
DNA Repair
DNA, Complementary
Fibroblasts
G2 Phase
Humans
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MutL Protein Homolog 1

Mutation

Neoplasm Proteins

Nuclear Proteins

Thioguanine

Transfection

Source

Open in PubMed

Identifiers

PMID: 9973196

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9973196-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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