Article
Genomic Instability Promoted by Overexpression of Mismatch Repair Factors in Yeast: A Model for Understanding Cancer Progression
13 Apr 2018
Abstract excerpt
Abstract Increased expression of mismatch repair proteins often correlates with tumor aggressiveness. Chakraborty, Dinh, and Alani report that co-overexpression of Msh2 and Msh6 in yeast results in genome instability phenotypes that are dependent on interaction with... Mismatch repair (MMR) proteins act in spellchecker roles to excise misincorporation errors that occur during DNA replication. Curiously,...