[Mutational analysis of p53 in T-cell lymphoblastic leukemia].

Abstract excerpt

BACKGROUND: p53 mutations were analysed in a consecutive series of patients with T-ALL from one hospital over a period of 9 years. PATIENTS AND METHOD: Thirty two samples from 27 patients with T-ALL were included in the study. Exons 5-9 were analysed using SSCP. RESULTS: A mutation at codon 273 was identified in a child in third relapse. The mutated clone became dominant in a sample obtained one month following a...

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